Lincrna Hotset Regulates Hox Gene Transcription and Promotes Early Hematopoietic Fates
نویسندگان
چکیده
منابع مشابه
HOX Antisense lincRNA HOXA-AS2 Promotes Tumorigenesis of Hepatocellular Carcinoma.
BACKGROUND Recent studies reveal that long non-coding RNAs (LncRNAs) play critical roles in the proliferation and migration of human cancer. Previous report has shown that LncRNA HOXA-AS2 was involved in carcinoma processes. However, the expression and biological function of HOXA-AS2 in hepatocellular carcinoma (HCC) are poorly understood. METHODS Quantitative real-time PCR (qRT-PCR) was perf...
متن کاملHOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor.
Homeobox genes are well known for their crucial role during embryogenesis but have also been found to be critically involved in normal and leukemic hematopoiesis. Because most previous studies focused on the role of aberrant HOX gene expression in leukemogenesis and because HOX-A10 is expressed in human CD34(+) precursor cells, this study investigated whether HOX-A10 also plays a pivotal role i...
متن کاملIkaros promotes early-born neuronal fates in the cerebral cortex.
During cerebral cortex development, a series of projection neuron types is generated in a fixed temporal order. In Drosophila neuroblasts, the transcription factor hunchback encodes first-born identity within neural lineages. One of its mammalian homologs, Ikaros, was recently reported to play an equivalent role in retinal progenitor cells, raising the question as to whether Ikaros/Hunchback pr...
متن کاملTailored Hox gene transcription and the making of the thumb.
References http://www.genesdev.org/cgi/content/full/22/3/293#References This article cites 27 articles, 8 of which can be accessed free at: service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box at the Topic collections (79 articles) Development (87 articles) Chromatin and Gene Expression Articl...
متن کاملA Hox-Eya-Pax complex regulates early kidney developmental gene expression.
During embryonic development, the anterior-posterior body axis is specified in part by the combinatorial activities of Hox genes. Given the poor DNA binding specificity of Hox proteins, their interaction with cofactors to regulate target genes is critical. However, few regulatory partners or downstream target genes have been identified. Herein, we demonstrate that Hox11 paralogous proteins form...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2014
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v124.21.1573.1573